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Figure 2 | BMC Biochemistry

Figure 2

From: The promoter of cell growth- and RNA protection-associated SND1 gene is activated by endoplasmic reticulum stress in human hepatoma cells

Figure 2

Ectopic expression of ATF6 transcription factor increases SND1 promoter activity. A) HepG2 cells were co-transfected with the SND/1-6 constructs of the human SND1 gene promoter and the ATF6 expression vector and used 24 hours later. Luciferase activity was measured in pCGN-ATF6 transfected cells (grey) and mock transfected cells (white, control) and expressed as fold increase respect to the activity of the SND/6 fragment in control cells. Data are presented as mean ± SD from at least three independent experiments. * P < 0.05, ** P < 0.01. B) Nucleotide sequence of human SND1 gene proximal promoter [GenBank: EF690304]. The transcription start site (+1) is shown in bold and marked by an arrow. Boxes indicate putative binding motives for ATF6 or transcription factors from CREB/ATF or EBOX/ATF subfamilies, and XBP1 binding sites are underlined.

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BMC Biochemistry

ISSN: 1471-2091

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