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Table 1 Position of the missense mutations affecting the sensitivity of ATCase to UTP.

From: Integrated allosteric regulation in the S. cerevisiae carbamylphosphate synthetase – aspartate transcarbamylase multifunctional protein

Mutants

Domain

Arg1076 →Ser

 

Asn1094 →Asp

 

Tyr1096 →Cys

CPSase

Trp1112 →Leu

 

Asp1220 →Tyr

 

Phe1924 →Val

 

Glu1933 →Lys

 

Glu1933 →Gly

 

Glu2052 →Lys

 

Gly2055 →Ser

ATCase

Asn2058 →Asp

 

Asn2157 →Lys

 

Glu2182 →Lys

 

Asp2186 →Asn

 
  1. All the mutants carry missense mutations leading to a single amino acids replacement. Five of them are located in the CPSase domains while the others are in the ATCase domain. In these mutants, ATCase is no longer inhibited by UTP although CPSase retains full sensitivity to this effector.
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BMC Biochemistry

ISSN: 1471-2091

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